K252AisastaurosporineanalogueisolatedfromaNocardiopsisstrainasapotentinhibitorofproteinkinaseC.K252Aexhibitspotentantitumoractivitybutshowsnoantimicrobialactivityinvitro,orinvivotoxicityinrodents.WhileK252AisapotentinhibitorofCa2+/calmodulinkinaseII,itisalsoactiveagainstotherkinases,notablymyosinlightchainkinase,cAMP-dependentproteinkinase(PKA),proteinkinaseC(PKC)andcGMP-dependentproteinkinase(PKG).
K252Aissolubleinethanol,methanol,DMForDMSO.Limitedwatersolubility.
CASNumber
99570-78-2
MolecularFormula
C26H19N3O5
MolecularWeight
453.5
StorageConditions
-20°C
Specifications: