GeninthiocinisathiopeptideantibioticisolatedfromaStreptomycessp.Geninthiocindisplaysa10-foldselectivityforbacteriaovermammaliancellslines,whereastherelateddedialanylgeninthiocinshowsthereverseselectivity.Geninthiociniscloselyrelatedtosiomycin,arecentlydiscoveredinhibitorofoncogenictranscriptionfactor,FoxM1.
GeninthiocinissolubleinDMForDMSO.Moderatelysolubleinmethanolorethanol.Poorwatersolubility.
CASNumber
158792-27-9
MolecularFormula
C50H49N15O15S
MolecularWeight
1132.1
MechanismofAction
GeninthiocinisapotentactivatorofthetipAgene,abacterialtranscriptionregulatorinvolvedinmultidrugresistance.
StorageConditions
-20°C