Fumitremorgin C is a tremorgenic mycotoxin isolated from Aspergillus fumigatus. It reverses multidrug resistance mediated by BCRP and increases cytotoxicity of several anticancer agents in vitro.
Fumitremorgin C is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
CAS Number
118974-02-0
Molecular Formula
C22H25N3O3
Molecular Weight
379.5
Mechanism of Action
Recent research has recognised fumitremorgin C as a potent and specific inhibitor of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter.
Storage Conditions
-20°C