Epothilone A is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Epothilone A has been investigated in clinical trials as an antitumor agent.
Epothilone A is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
CAS Number
152044-53-6
Molecular Formula
C26H39NO6S
Molecular Weight
493.7
Mechanism of Action
Epothilone A acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity.
Storage Conditions
-20°C
Appearance
White to off white powder