ConcanamycinAisthemajoranalogueoftheconcanamycincomplexproducedbyStreptomycessp..Ithasbeenshowntoactasapotentandspecificvacuolar-ATPaseinhibitor.ConcanamycinAinhibitstheacidificationoforganellesandblockscellsurfaceexpressionofviralenvelopeglycoproteinswithoutaffectingtheirsynthesis.Italsointerfereswithintracellularproteintraffickingandinhibitsperforin-andFas-basedlyticpathwaysincell-mediatedcytotoxicity.Concanamycinsarestructurallyrelatedtothebafilomycins.
CASNumber
80890-47-7
MolecularFormula
C46H75NO14
MolecularWeight
866.1
MechanismofAction
ConcanamycinAinhibitstheacidificationoforganellesandblockscellsurfaceexpressionofviralenvelopeglycoproteinswithoutaffectingtheirsynthesis.Italsointerfereswithintracellularproteintraffickingandinhibitsperforin-andFas-basedlyticpathwaysincell-mediatedcytotoxicity.
StorageConditions
-20°C