ChromomycinA3isthemajorcomponentofthechromomycincomplexoftheaureolicacidclass,isolatedfromseveralStreptomycesspecies,andfirstreportedin1960.ChromomycinA3exhibitsabroad
icalprofileasanantibacterial,antifungalandantitumoragent.TheintenseUVspectrumandstrongfluorescencemakeschromomycinausefulstainforDNA.
ChromomycinA3issolublein ethanol,methanol,DMFandDMSO.
CASNumber
7059-24-7
MolecularFormula
C57H82O26
MolecularWeight
1183.3
MechanismofAction
ChromomycinA3bindsreversIBLytoGC-specificDNAligandintheminorgroovewhichinhibitstranscription,DNAgyraseandtopoisomeraseIIactivity.
StorageConditions
-20°C