Apoptolidin,originallyisolatedfromaNocardiopsissp.,inducesapoptoticcelldeathinratglialcellstransformedwiththeadenovirusE1Aoncogene(IC50=11ng/ml).ApoptolidinisamongthemostselectivecytotoxicagentstestedbytheNCIinhumancancercelllines.
CASNumber
194874-06-1
MolecularFormula
C58H96O21
MolecularWeight
1129.4
MechanismofAction
TheapoptoticactivityofapoptolidincorrelateswithF0F1-ATPaseinhibition;however,recentevidencesuggeststheexistenceofasecondaryBIOLOGicaltargetormorecomplexmodeofaction.
StorageConditions
-20°C