Apoptolidin, originally isolated from a Nocardiopsis sp., induces apoptotic cell death in rat glial cells transformed with the adenovirus E1A oncogene (IC50 = 11 ng/ml). Apoptolidin is among the most selective cytotoxic agents tested by the NCI in human cancer cell lines.
Apoptolidin is soluble in ethanol, methanol, DMF and DMSO and has limited water solubility.
CAS Number
194874-06-1
Molecular Formula
C58H96O21
Molecular Weight
1129.4
Mechanism of Action
The apoptotic activity of apoptolidin correlates with F0F1-ATPase inhibition; however, recent evidence suggests the existence of a secondary biological target or more complex mode of action.
Storage Conditions
-20°C