Minocyclineisasemi-synthetictetracyclinepreparedbysequentialhydrogenolysis,nitrationandreductivemethylation.Minocycline,togetherwithdoxycycline,isregardedasa"thirdgeneration"tetracyclinelargelyreplacingthenaturalproductsandpro-drugsproducedintheearly1950sformainstreamantibioticapplications.Likealltetracyclines,minocyclineshowsbroadspectrumantibacterialandantiprotozoanactivity. Minocyclinehasbeenextensivelycitedintheliteraturewithover5,000references.
Minocyclineissolubleinethanol,methanol,DMForDMSO.Limitedwatersolubility.
CASNumber
10118-90-8
MolecularFormula
C23H27N3O7
MolecularWeight
457.5
MechanismofAction
Minocyclineactsbybindingtothe30Sand50Sribosomalsub-units,blockingproteinsynthesis.
StorageConditions
-20°C