PyridomycinisapotentantibioticactiveagainstmycobacteriaandsomeGramnegativebacteria,originallyisolatedfromStreptomyces
doflavusbyUmezawagroupattheNIHJapanin1953,andsinceisolatedfromdifferentspeciesandpublishedunderseveralnames.Theunusual12-memberedmacrocyclicdepsipeptidecomprisesthreeuniquesub-unitsincorporatingtwosubstitutedpyridines.Recentreportsofactivityagainstisoniazid-resistantmycobacteriahasseenpyridomycinidentifiedasapotentialleadfornewgenerationantibiotics.
Pyridomycinissolublein ethanol,methanol,DMFandDMSO.
CASNumber
18791-21-4
MolecularFormula
C27H32N4O8
MolecularWeight
186.2
MechanismofAction
PyridomycinisthoughttotargetNADH-dependentenoyl(acyl-carrier-protein)reductaseInhA.
StorageConditions
-20°C