Cefpodoxime free acid is a third generation cephalosporin β-lactam antibiotic.

TOKU-E offers three forms of cefpodoxime: cefpodoxime proxetil (C015), cefpodoxime sodium salt (C096), and cefpodoxime free acid (C016). All forms are soluble in DMSO (dimethyl sulfoxide).

Alm et al. used cefpodoxime from TOKU-E against Escherichia coli NDM isolates in microdilution MIC assays. "Characterization of Escherichia coli NDM isolates with decreased susceptibility to aztreonam/avibactam: role of a novel insertion in PBP3." 

CAS Number

80210-62-4

Molecular Formula

C₁₅H₁₇N₅O₆S₂

Molecular Weight

427.46 g/mol

Mechanism of Action

Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. However, like many cephalosporins, cefpodoxime is stable in the presence of β-lactamases.

Storage Conditions

-20°C, protect from light

Tariff Code

2941.90.5000

Spectrum

Cefpodoxime free acid is a broad spectrum antibiotic which targets a wide variety of gram positive and gram negative bacteria especially those which cause otitis media and pharyngitis.

Specifications: