Ceftriaxone sodium is a third generation cephalosporin antibiotic and is freely soluble in aqueous solution (105 mg/mL).

CAS Number

104376-79-6

Molecular Formula

C₁₈H₁₆N₈Na₂O₇S₃ · 3.5 H₂O

Mechanism of Action

Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Like many cephalosporins, ceftriaxone is resistant to a number of β-lactamases.

Storage Conditions

-20°C

Tariff Code

2941.90.5000

Spectrum

Ceftriaxone sodium is a broad spectrum antibiotic targeting a wide variety of gram positive and gram negative bacteria.

Specifications: