The tetramic acid, equisetin, is produced by a number of species of Fusarium. Interest in equisetin emerged with reports of its inhibitory activity against HIV-1 integrase in vitro that was mechanistically distinct from previously described inhibitors. Equisetin inhibits 3' end-processing and strand transfer, as well as disintegration catalysed by either the full-length enzyme or the truncated integrase core.
Equisetin is soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.
CAS Number
57749-43-6
Molecular Formula
C22H31NO4
Molecular Weight
373.5
Storage Conditions
-20°C
Specifications:
Appearance
Light tan to tan solid