ReveromycinA,thedominantanalogueofacomplexofspiroketalsisolatedfromaStreptomycessp.,isaninhibitorofthemitogenicactivityofEGF.ReveromycinAdisplaysantiproliferativebehaviouragainsthumancelllinesKBandK562,aswellaspotentantifungalactivity.Morerecentlyithasbeenshowntoinduceapoptosisinosteoclaststhusinhibitingboneresorption.
ReveromycinAissolublein ethanol,methanol,DMFandDMSO.
CASNumber
134615-37-5
MolecularFormula
C36H52O11
MolecularWeight
660.8
MechanismofAction
ReveromycinAisaG1phasecellcycleinhibitor,selectivelyinhibitingisoleucyl-tRNAsynthetase.
StorageConditions
-20°C