Pseurotin A is a fungal metabolite with an unusual hetero-spirocyclic ring system. It has potent neuritogenic activity in PC12 phaechromocytoma cells, a useful model for adrenergic neuronal differentiation. Pseurotin A also exhibits chitinase inhibition and acts synergistically with azole antifungal agents.
Pseurotin A is soluble in ethanol, methanol, DMF and DMSO.
CAS Number
58523-30-1
Molecular Formula
C22H25NO8
Molecular Weight
431.4
Mechanism of Action
Pseurotin A induces multipolar and branching neurites comparable to β-NGF, an endogenous neurotrophic factor.
Storage Conditions
-20°C