DoramectinisabiosyntheticavermectinderivedfromamutantstrainofStreptomycesavermitilis,supplementedwithacyclohexylcaboxylicacidstartingunit.Doramectinwasdevelopedasananthelminticforinternalparasitecontrol.Thepresenceofthecyclohexylgroupreplacingthesec-butylmoietyaffordsgreaterhydrophobicityandlonger
BIOLOGicalhalf-lifecomparedtoavermectin.Liketheothermilbemycin/avermectins,itselectivelybindstoparasiteglutamate-gatedchlorideionchannelsanddisruptsneurotransmissionle
ADIngtoparalysisanddeathoftheparasite.
Doramectinissolublein ethanol,methanol,DMFandDMSO.
CASNumber
165108-44-1
MolecularFormula
C43H62O11
MolecularWeight
610.7
StorageConditions
-20°C
Specifications: