Flumequine is a first generation fluoroquinolone antibiotic commonly used in veterinary medicine for enteric infections. Flumequine is freely soluble in dilute solutions of alkali hydroxides.
CAS Number
42835-25-6
Molecular Formula
C14H12FNO3
Molecular Weight
261.25
Mechanism of Action
Fluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited.
Storage Conditions
Ambient
Tariff Code
2933.99.7900
Spectrum
Flumequine targets primarily gram negative bacteria, especially those which cause enteric infections in animals.
Form
Powder
Appearance
White Crystalline Powder
Source
Synthetic
Impurity Profile
Impurity A| (RS)-5-methyl-1-oxo-6,7-dihydro-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid (defluoroflumequine)||||
Impurity B| ethyl (RS)-9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-benzo[i,j]quinolizine-2-carboxylate (flumequine ethyl ester)||||
Melting Point
253-255°C
Optical Rotation
-0.1° to +0.1°
Assay
(On Dried Basis): 99.0-101.0%
Loss on Drying
≤0.5%