Micafunginisasemi-syntheticcycliclipopeptidebelongingtotheechinocandinclassthatwasreportedin1999fromFujisawainJapan.Unlikeothermarketedsemi-syntheticderivativesinthisclass,micafunginisnotderivedfromechinocandinbutratherfromFR901379whichcontainsaphenolicsulfatetoenhanceaqueoussolubility,aseriouslimitationintheclass.
Micafunginissolubleinethanol,methanol,DMForDMSO.Moderatewatersolubility.
CASNumber
235114-32-6
MolecularFormula
C56H71N9O23S
MolecularWeight
1270.3
MechanismofAction
Micafungininhibitsthesynthesisofβ-(1,3)-D-glucan,anessentialcomponentofthecellwallofsusceptIBLefungiandisextensivelyreferencedintheliteraturewithover700citations.
StorageConditions
-20°C