Leptomycin A, a methyl analogue of leptomycin B, is a minor component of the leptomycin complex produced by selected Streptomyces species. Leptomycin B is a potent inhibitor of the nuclear transport receptor CRM1. Leptomycin A is also likely to inhibit nuclear transport and may offer differences in exporter selectivity. Leptomycin A shows antimicrobial activity against Schizosaccaromyces pombe and Mucor rouxianus.
Leptomycin A is soluble in ethanol or methanol. Poor water solubility. Ethanol recommended. Unstable in DMSO.
CAS Number
87081-36-5
Molecular Formula
C32H46O6
Molecular Weight
526.7
Storage Conditions
-20°C
Specifications:
Appearance
Colourless Film