Form

Powder

Appearance

Yellow powder

Source

Synthetic

Impurity Profile

Impurity A| 1-Cyclopropyl-6,8-difluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Moxifloxacin Difluoro Analog|151213-15-9|C₂₀H₂₁F₂N₃O₃|389.40| Impurity B| 1-Cyclopropyl-6,8-dimethoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Moxifloxacin Dimethoxy Analog||C₂₂H₂₇N₃O₅|413.47| Impurity C| 1-Cyclopropyl-8-ethoxy-6-fluoro-7-[(4aS,7aS)-octahydro-6H-pyrrolo [3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Moxifloxacin Ethyl Analog||C₂₂H₂₆FN₃O₄|415.46| Impurity D| 1-Cyclopropyl-8-fluoro-6-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo [3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Moxifloxacin Isomer|1029364-77-9|C₂₁H₂₄FN₃O₄|401.43| Impurity E| 1-Cyclopropyl-6-fluoro-8-hydroxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo [3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Moxifloxacin Desmethyl Analog||C₂₀H₂₂FN₃O₄|387.4| Moxifloxacin Decarboxy Analog| Decarboxy Moxifloxacin;1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline||C₂₀H₂₄FN₃O₂|357.42| Moxifloxacin Difluoro Hydroxy Impurity| 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-hydroxy-4-oxo-3-quinoline carboxylic acid|154093-72-8|C₁₃H₉F₂NO₄|281.21| Moxifloxacin Difluoro Methoxy Impurity| 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid|112811-72-0|C₁₄H₁₁F₂NO₄|295.24| Moxifloxacin N-Methyl Analog| 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-1-methyl-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid hydrochloride||C₂₂H₂₇ClFN₃O₄|451.92| Moxifloxacin Trifluoro Ethyl Ester| 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid ethyl ester|94242-51-0|C₁₅H₁₂F₃NO₃|311.26| Moxifloxacin Trifluoro Impurity| 1-Cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-3-quinoline carboxylic acid|94695-52-0|C₁₃H₈F₃NO₃|283.20| Moxifloxacin Methyl Ester| 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid methyl ester|721970-35-0|C₂₂H₂₆FN₃O₄|415.46| Moxifloxacin Hydrochloride| 1-Cyclopropyl-6-fluoro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride|186826-86-8|C₂₁H₂₅ClFN₃O₄|437.89|

Water Content (Karl Fisher)

≤4.5%

pH

3.9-4.6

Assay

(HPLC, As Is): ≥98.0%