Enramycin (also known as Enduracidin and Enradin) is a polypeptide antibiotic produced by Streptomyces fungicidus and developed as a food additive in Japan. Enramycin is slightly soluble in water and freely soluble in dilute HCl solution. Enramycin is composed of two different compounds: enramycin A and enramycin B. The ratios of enramycin A to enramycin B varies but is typically ~70:30.

TOKU-E offers three forms of enramycin: enramycin (E006), enramycin A, EvoPure® (E018), and enramycin B, EvoPure® (E019). EvoPure® products are single antibiotic fractions, most >99% pure.

CAS Number

11115-82-5

Molecular Formula

Enramycin A: C₁₀₇H₁₃₈Cl₂N₂₆O₃₁
Enramycin B: C₁₀₈H₁₄₀Cl₂N₂₆O₃₁

Molecular Weight

Enramycin A: 2550.21
Enramycin B: 2564.24

Mechanism of Action

Enramycin acts as a MurG inhibitor involved peptidoglycan synthesis in gram positive bacteria. MurG catalyzes the transglycosylation reaction in the last step of peptidoglycan biosynthesis. Inhibition of this step greatly compromises cell wall integrity leading to cell lysis.

Storage Conditions

-20°C

Tariff Code

2941.90.1050

Spectrum

Enramycin has a strong antibacterial activity against Gram-positive bacteria and inhibits development of major gut flora pathogens. Resistance or cross-resistance with existing antibiotics has rarely been observed.

Specifications: