Piperacillin is an extended spectrum β-lactam antibiotic and resistant to many β-lactamases.
TOKU-E offers two forms of piperacillin: piperacillin (P017) and piperacillin sodium (P010). Piperacillin is sparingly soluble in aqueous solution at 0.119 mg/mL. Piperacillin sodium is freely soluble in aqueous solution.
61477-96-1
C23H27N5O7S
517.55
β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.
2-8 °C
2941.10.5000
Piperacillin is a broad spectrum antibiotic targeting a wide range of susceptible gram positive and gram negative bacteria.
Powder
White crystalline powder
Semi-synthetic
Related Substances:
Impurity A: ≤ 1.0%
Impurity B: ≤ 0.2%
Impurity C: ≤ 0.4%
Impurity D: ≤ 2.0%
Ampicillin: ≤ 0.2%
2.0-4.0%
2.0-4.5
+155° to +175°
(on dried basis): 96.0-103.0%
≤ 0.002%
