Piperacillin is an extended spectrum β-lactam antibiotic and is resistant to many β-lactamases.

TOKU-E offers two forms of piperacillin: piperacillin (P017) and piperacillin sodium (P010). Piperacillin is sparingly soluble in aqueous solution at 0.119 mg/mL. Piperacillin sodium is freely soluble in aqueous solution.

CAS Number

59703-84-3

Molecular Formula

C₂₃H₂₆N₅NaO₇S

Molecular Weight

539.54

Mechanism of Action

β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases.

Storage Conditions

2-8 C

Tariff Code

2941.10.5000

Spectrum

Piperacillin is a broad spectrum antibiotic targeting a wide range of susceptible gram positive and gram negative bacteria.

Specifications: