Form
Powder
Appearance
Off-whitepowder
Source
Synthetic
Absorbance
UVmax(95%ethanol):224,266,274nm(ε13,700,800,700).
MeltingPoint
164.3-166.3°C
Thiamphenicolisabacteriostaticantibioticderivedfromchloramphenicol.Likechloramphenicol,thiamphenicolisinsolubleinwaterbuthighlysolubleinlipids.
15318-45-3
C12H15Cl2NO5S
356.22g/mol
Boththiamphenicolandchloramphenicolworkbythesamemechanism,however,thiamphenicolisabout3Xaspotent.Afterenteringabacterialcell,thiamphenicolbindstothe50Sribosomalsubunitpreventingpeptidebondformation.ResistancetothiamphenicolmaybeduetodecreasedcellpermeABIlityoramutationinthe50Sribosomalsubunit.
2-8°C,protectfromlight
2941.40.0000
ThiamphenicolisabroadspectrumantibioticcommonlyusedtotargetbacteriaresponsIBLeforcausingsexuallytransmitteddiseases.
Powder
Off-whitepowder
Synthetic
UVmax(95%ethanol):224,266,274nm(ε13,700,800,700).
164.3-166.3°C