Methacycline HCl is a member of the tetracycline antibiotics and is more active against Gram-negative and Gram-positive bacteria than tetracycline and demethylchlortetracycline.
CAS Number
3963-95-9
Molecular Formula
C22H22N2O8 • HCl
Molecular Weight
478.88
Mechanism of Action
Methacycline inhibits protein synthesis by preventing amino-acyl tRNA from binding to the “A” site in the bacterial ribosome.
Storage Conditions
≤30°C
Spectrum
Metacycline has a broad spectrum of activity and is effective against several clinically significant pathogenic bacteria.
Appearance
Yellow crystalline powder
Source
Semi-synthetic
Impurity Profile
Oxytetracyline: Not more than 1.0%
Doxycycline: Not more than 2.0%
Other impurities: Not more than 0.5%
Total impurities: Not more than 3.0%
Water Content (Karl Fisher)
Not more than 2.0%
pH
2.0 - 3.0
Assay
Not less than 877 Units/mg
