MethacyclineHClisamemberofthetetracyclineantibioticsandismoreactiveagainstGram-negativeandGram-positivebacteriathantetracyclineanddemethylchlortetracycline.
CASNumber
3963-95-9
MolecularFormula
C22H22N2O8 •HCl
MolecularWeight
478.88
MechanismofAction
Methacyclineinhibitsproteinsynthesisbypreventingamino-acyltRNAfrombindingtothe“A”siteinthebacterialribosome.
StorageConditions
≤30°C
Spectrum
Metacyclinehasabroadspectrumofactivityandiseffectiveagainstseveralclinicallysignificantpathogenicbacteria.
Appearance
Yellowcrystallinepowder
Source
Semi-synthetic
ImpurityProfile
Oxytetracyline:Notmorethan1.0%
Doxycycline:Notmorethan2.0%
Otherimpurities:Notmorethan0.5%
Totalimpurities:Notmorethan3.0%
WaterContent(KarlFisher)
Notmorethan2.0%
pH
2.0-3.0
Assay
Notlessthan877Units/mg