Nosiheptideisabicyclicthiopeptideantibioticproducedbyseveralspeciesofactinomycetes,notablyStreptomyces,firstreportedbyJapaneseresearchersin1970.Unlikeotherbicyclicthiopeptidessuchasthiostrepton,thesecondmacrocyclicringislinkedbyrelativelyfragilelactoneandthiolactonebridgestothecorecyclicpeptide.Nosiheptidehasbroadspectrumantibacterialactivity,andhasrecentlydemonstratedaprolongedpost-antibioticeffectinbothnosocomialandcommunity-acquiredMRSAcomparedwithvancomycin.Despiteitslonghistoryinanimalhealth,nosiheptidehasnotbeenextensivelystudiedandisregardedasa"lostantibiotic"largelyescapingintensiveinvestigationforhumanapplication.
Nosiheptideissolubleinethanol,methanol,DMForDMSO.
CASNumber
56377-79-8
MolecularFormula
C51H43N13O12S6
MolecularWeight
1222.4
StorageConditions
-20°C
Specifications: