Virginiamycin complex is defined as a mixture of 75% ostreogrycin A (virginiamycin M1) and 25% virginiamycin S1, together with the less abundant S analogues. As the two major components have quite different solubilities, these proportions are not readily achieved or used. The composition of the complex is important as Virginiamycin S1 acts a synergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A.
Virginiamycin is soluble in DMF and DMSO.
CAS Number
11006-76-1
Molecular Formula
C28H35N3O7 (for M1), C43H49N7O10 (for S1)
Molecular Weight
525.6 (for M1); 823.9 (for S1)
Storage Conditions
-20°C