UCN-01 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture. UCN-01 enhances the cytotoxicity of other anti-cancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by the latter agents.
UCN-01 is soluble in ethanol, methanol, DMF and DMSO.
CAS Number
112953-11-4
Molecular Formula
C28H26N4O4
Molecular Weight
482.5
Mechanism of Action
UCN-01 inhibits protein kinase C (PKC) and cyclin-dependant kinase 2 (CDK2), resulting in accumulation of cells in the G1 phase and induction of apoptosis.
Storage Conditions
-20°C