Tiamulinisasemi-syntheticanalogueofpleuromutilininwhichthehydroxyacetylsidechainisreplacedwithalargerdiethylaminoethylthioacetylmoiety,providinggreaterhydrophobicityandanionisablegroupforsaltformationandgreaterwatersolubility.TiamulinisapotentandhighlyselectiveantibioticactiveagainstarangeofGrampositivebacteria,withnocrossresistancetoexistingantibioticclassesduetoitsuniquemodeofaction.Likepleuromutilin,itinhibitsproteinsynthesisbybindingtodomainVof23SrRNA.
Tiamulinissolubleinethanol,methanol,DMFandDMSO.
CASNumber
55297-95-5
MolecularFormula
C28H47NO4S
MolecularWeight
493.7
StorageConditions
-20°C
Specifications:
Appearance
Evaporatedresin