Thefungalmetabolite,thielavinA,anditsrelativesareglucose-6-phosphataseinhibitors.Thethreebenzoicacidunitsareessentialforinhibition.ThielavinAwasoriginallyisolatedasainhibitorofprostaglandinbiosynthesis.ThecloselyrelatedthielavinBisatelomeraseandcellwalltransglycosylationinhibitor.
ThielavinAissolubleinethanol,methanol,DMFandDMSO.
CASNumber
71950-66-8
MolecularFormula
C29H30O10
MolecularWeight
538.5
MechanismofAction
ThielavinAinhibitsglucose-6-phosphatase.
StorageConditions
-20°C