SaccharocarcinBisanunusualtetronicacidstructurallyrelatedtokijanimicin,chlorothricin,tetrocarcinsandversipelostatin,whichhaspronouncedactivityagainstGrampositivebacteriaandChlamydiatrachomatis.Limitedavail
lityhasrestrictedfurtherinvestigationofthismetabolite,howeverseveralmembersofthisclasshavereceivedconsiderableliteraturefocus.
CASNumber
158475-33-3
MolecularFormula
C68H103NO20
MolecularWeight
1254.6
MechanismofAction
VersipelostatininhibitstranscriptionfromthepromoterofGRP78,agenethatisactivatedaspartofastresssignallingpathwayunderglucosedeprivationresultinginunfoldedproteinresponse(UPR),causingdeathofglucose-deprivedcells.TetrocarcinAappearstotargetthephosphatidylinositide-3"-kinase/Aktsignallingpathway.
StorageConditions
-20°C