Pleuromutilin is a diterpene produced by several species of basidomycete, notably the genus Pleurotus, discovered in 1951. Pleuromutilin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action.
Pleuromutilin is soluble in ethanol, methanol, DMF and DMSO.
CAS Number
125-65-5
Molecular Formula
C22H34O5
Molecular Weight
378.5
Mechanism of Action
Pleuromutilin inhibits protein synthesis by binding to domain V of 23S rRNA and this has led to the development of many semi-synthetic analogues as new generation antibiotics, such as tiamulin and retapamulin.
Storage Conditions
-20°C