Pleuromutilinisaditerpeneproducedbyseveralspeciesofbasidomycete,notablythegenusPleurotus,discoveredin1951.PleuromutilinisapotentandhighlyselectiveantibioticactiveagainstarangeofGrampositivebacteria,withnocrossresistancetoexistingantibioticclassesduetoitsuniquemodeofaction.
Pleuromutilinissoluble inethanol,methanol,DMFandDMSO.
CASNumber
125-65-5
MolecularFormula
C22H34O5
MolecularWeight
378.5
MechanismofAction
PleuromutilininhibitsproteinsynthesisbybindingtodomainVof23SrRNAandthishasledtothedevelopmentofmanysemi-syntheticanaloguesasnewgenerationantibiotics,suchastiamulinandretapamulin.
StorageConditions
-20°C