Pirlimycinisasemi-syntheticlincosamidepreparedfromclindamycinbyhydrolysingthepropylN-methylprolineandre-annealinga4-ethylpipecolicacid.Pirlimycinismorehydrophobicthanclindamycinandismorepotentagainstanumberofimportantpathogens.Likeothermembersofthelincosamidefamily,pirlimycinisabroadspectrumantibioticwithactivityagainstanaerobicbacteriaandprotozoans.Pirlimycinhasbeenlessextensivelyresearchedthantheolderlincosamides.
Pirlimycinissolubleinethanol,methanol,DMForDMSO.Goodwatersolubility.
CASNumber
79548-73-5
MolecularFormula
C17H31ClN2O5S
MolecularWeight
410.2
MechanismofAction
Pirlimycinactsbybindingtothe23Sribosomalsubunit,blockingproteinsynthesis.
StorageConditions
-20°C