Nargenicin(CP-47,444)isa10-memberedmacrocycliclactoneisolatedfromNocardiain1980asanantibiotic.Themacrocycliclactoneisanchoredthroughvicinalcarbonstoadecalinbearingapyrroleester.NargenicinexhibitspotentactivityagainstGrampositivebacteria,inparticularMRSAstrains.Morerecently,nargenicinhasbeenshowntoenhanceretinoate-inducedcelldifferentiation.
Nargenicinissolubleinethanol,methanol,DMForDMSO.Limitedwatersolubility.
CASNumber
75923-01-2
MolecularFormula
C29H39NO10
MolecularWeight
561.6
StorageConditions
-20°C
Specifications: