Amphomycin is a lipopeptide antibiotic produced by Streptomycetes and Actinoplanes, initially reported by researchers at Bristol-Myers in 1953 from Streptomyces canus. Amphomycin was marketed as a complex of closely related analogues in the 1950s and 1960s. Structure elucidation was not completed until 2000. Amphomycin is closely related to a number of "lost" antibiotics, aspartocin, crystallomycin, glumamycin, friulimicin, laspartocin, tsushimycin and zaomycin. Interest in amphomycin was re-awakened with the discovery of friulimicin activity against antibiotic resistant strains.
Amphomycin is soluble in ethanol, methanol, DMF and DMSO.
CAS Number
1402-82-0
Molecular Formula
C58H91N13O20
Molecular Weight
1290.4
Mechanism of Action
Amphomycin inhibits peptidoglycan synthesis and blocks cell wall development.
Storage Conditions
-20°C