Fidaxomicinisarecentlymarketedantibioticwithaconfusinghistorydatingbacktoitsoriginalisolationin1975.Fidaxomicinisthemajoranalogueofafamilyofmacrocycliclactones,isolatedindependentlybythreedifferentgroupsfromculturesbelongingtothreedifferentgenera(Actinoplanes,DactylosporangiumandMicromonospora)knownaslipiarmycinA3,tiacumicinBandclostomicinB1,respectively.FidaxomicinisanarrowspectrumantibioticwithexcellentactivityagainstGrampositivebacteria,notablyClostridiumdifficile.Fidaxomicinactsinthegastrointestinaltractwithoutunduedisruptiontogutmicrobialflora.
Fidaxomicinissolubleinethanol,methanol,DMForDMSO.Limitedwatersolubility.
CASNumber
873857-62-6
MolecularFormula
C52H74Cl2O18
MolecularWeight
1058.0
StorageConditions
-20°C
Specifications: