Azamulinisasemi-syntheticpleuromutilinpreparedbysequentialreactionofdihydropleuromutilintosylatewith2-amino-1,2,4-triazole-5-thiol.Whileazamulinisabroadspectrumantibioticinthepleuromutilinclass,thisaspectofitsbioprofilehasreceivedlittleattention.Infact,thetriazolesubstituentaddedtonominallyimprovethedrug"sbioavail
ABIlity,impartedanunusualselectivityfortheinhibitionofspecificcytochromeP450mixedfunctionoxidasesub-types,importantforunderstandingthemannerinwhichthebodymetabolisesdrugsorxenobiotics.
Azamulinissolublein ethanol,methanol,DMFandDMSOandhaslimitedwatersolubility.
CASNumber
76530-44-4
MolecularFormula
C24H36N4O4S
MolecularWeight
476.6
StorageConditions
-20°C
Specifications: