Methotrexatesodiumsaltisaselectiveagentfordihydrofolatereductase(DHFR)-transfectedcells,andanucleicacidsynthesisinhibitorinproteinexpressionsystems,thuscanbeusedasanancillarymaterialinupstreambiomanufacturingapplications.Italsohasimmunosuppressiveeffectsforrheumatoidarthritisresearchandhasanti-cancerproperties.Methotrexatesodiumsaltisfreelysolubleinaqueoussolution.
Wealsooffer:
- Methotraxate(M027)
- Methotrexate,EvoPure®(M091)
Thisproductisconsideredadangerousgood.Quantitiesabove1gmaybesubjecttoadditionalshippingfees.Pleasecontactusforquestions.
CASNumber
7413-34-5
MolecularFormula
C20H20N8Na2O5
MolecularWeight
498.40
MechanismofAction
Incancerouscells,Methotrexateactsasanallostericinhibitorofdihydrofolatereductase(DHFR),anenzymeinvolvedinthefolicacidmetabolicpathway.Folicacidisessentialincellsbecauseitisrequiredforthymidineandpurinesynthesis.Methotrexatethereforeactsasanucleicacidsynthesisinhibitor.
StorageConditions
-20°C
TariffCode
2933.59.2600
