CyclosporinCisahydroxylatedmetaboliteofcyclosporinA(CsA).CyclosporinChasbeenfoundtohavesimilarimmunosuppressantactivity,butlowernephrotoxicitythancyclosporinA(CsA).CyclosporinChasalsobeenfoundtohaveantimycoticproperties.

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CASNumber

59787-61-0

MolecularFormula

C₆₂H₁₁₁N₁₁O₁₃

MolecularWeight

1218.6g/mol

MechanismofAction

CyclosporinC(andothercyclosporinA(CsA)metabolites)havelowerimmunosuppressantactivitybutmostlikelyoperateunderthesamemechanismascyclosporinA(CsA)describedbelow.

CyclosporinA(CsA)immunosuppressantactivitystemsfromitsABIlitytopreventT-cellactivationbyblockingspecificcytokinetranscriptiongenes.AfterenteringaT-cell,cyclosporinA(CsA)associateswithubiquitouscytosolicproteinscalledcyclophilinswhichaidinproteinfolding.CyclosporinA(CsA):cyclophilincomplexestogetherbindcalcineurin,(anothercytosolicprotein)effectivelyblockingthepathwaytoIL-2genetranscriptionandT-cellactivation.

StorageConditions

-20°C

TariffCode

2933.79.8500