CyclosporinDisahydroxylatedmetaboliteofcyclosporinA.CyclosporinDandothercyclosporinmetaboliteshavebeenfoundtohavelower(<10%)immunosuppressantactivitythancyclosporinA.CyclosporinDhasbeenfoundtoreversedaunorubicinresistanceinsomeresistantleukemiacellsbypossIBLyinhibitingtheeffluxfunctionsofP-glycoprotein.

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CASNumber

63775-96-2

MolecularFormula

C₆₃H₁₁₃N₁₁O₁₂

MolecularWeight

1216.63g/mol

MechanismofAction

CyclosporinB(andothercyclosporinAmetabolites)havelowerimmunosuppressiveactivitybutlikelyoperateunderthesamemechanismascyclosporinAdescribedbelow.AfterenteringaT-cell,CyclosporinAassociateswiththecytosolicproteincyclophilinwhichhelpsinproteinfolding.CyclosporinAbindstocyclophilinsandthiscomplexbindsanothercytosolicproteinphosphatasecalledCalcineurin(proteinphosphatase2B)thatdephosphorylatesatranscriptionfactor(nuclearfactorofactivatedT-cells,orNF-AT)neededforexpressionofinterleukin2(IL-2.).Italsoblocksthepathwaytonitricoxidesynthesisviatumornecrosisfactor(TNFa)andInterleukin1a.

StorageConditions

-20°C

TariffCode

2933.79.8500