Amoxicillinisanextendedspectrumβ-lactamantibioticsimilarinstructuretoAmpicillin.ResistancetoAmoxicillincanbeattributedtoβ-lactamaseenzymessecretedbyresistantcells.TOKU-EoffersthreeformsofAmoxicillin:
- AmoxicillinTrihydrate(A004)
- AmoxicillinSodium(A059)
- Amoxicillin:PotassiumClavulanate(2:1)(A054)
AmoxicillinTrihydrateiseffectiveagainstavarietyofGram-negativeandGram-positivebacteria.Thecompoundisslightlysolubleinwater.
CASNumber
61336-70-7
MolecularFormula
C16H19N3O5S•3H2O
MolecularWeight
419.45
MechanismofAction
Likeallβ-lactams,amoxicillintargetsPBP’s(penicillinbindingproteins)involvedinthefinalphaseofpeptidoglycansynthesis.PBP’sareenzymeswhichcatalyzeapentaglycinecrosslinkbetweenalanineandlysineresidues.Withoutapentaglycinecrosslink,theintegrityofthecellwallisseverelycompromisedultimatelyleADIngtothedeathofthecell.
StorageConditions
2-8°C
TariffCode
2941.10.5000
Spectrum
Amoxicillintargetsawiderangeofβ-lactamasenegativeGrampositiveandGramnegativebacteriaincludingE.coliandanumberofStreptococcusandStaphylococcusspecies.Interestingly,amoxicillinhasbeenfoundtobeeffectiveagainstcertainβ-lactamsensitiveVREorvancomycinresistantEnterococcus;aglycopeptideantibioticresistant"superbug."
