AmpicillinAnhydrousisamemberoftheβ-lactamfamilyandissimilarinstructuretopenicillin.
TOKU-EoffersfiveformsofAmpicillin:
- AmpicillinAnhydrous(A043)
- AmpicillinSodium(A042)
- Ampicillin/Sulbactam(2:1)(A071)
- AmpicillinTrihydrate,USP(A009)
- AmpicillinTrihydrate,EP(A020)
AmpicillinAnhydrousisthemoststableandpureformthatTOKU-Eoffers.Itissparinglysolubleinwaterandfreelysolublein1NNH4OH(50mg/mL).
CASNumber
69-53-4
MolecularFormula
C16H19N3O4S
MolecularWeight
349.40
MechanismofAction
Likeallβ-lactams,AmpicillininterfereswithPBP(penicillinbindingprotein)activityotherwiseinvolvedinthefinalphaseofpeptidoglycansynthesis.PBP’sareenzymeswhichcatalyzeapentaglycinecrosslinkbetweenalanineandlysineresidues.Withoutapentaglycinecrosslink,theintegrityofthecellwallisseverelycompromisedultimatelyleADIngtocelllysis.
StorageConditions
2-8°C
TariffCode
2941.10.1000
Spectrum
AmpicillintargetsGram-negative,nonESBL(ExtendedSpectrumβ-lactamase)bacteriaincludingStaphylococcusandStreptococcusandmedicallyimportantentericpathogenssuchasShigellaandSalmonella.Interestingly,ampicillinhasbeenfoundtobeeffectiveagainstcertainβ-lactamsensitiveVREorvancomycinresistantEnterococcus;aglycopeptideantibioticresistant"superbug."
