Ampicillin/Sulbactamisacombinationofaβ-lactamsimilarinstructuretopenicillin,withaβ-lactamaseinhibitorusedtoincreasepotencyofβ-lactamantibiotics.
TOKU-EoffersfiveformsofAmpicillin:
- Ampicillin/Sulbactam(2:1)(A071)
- AmpicillinAnhydrous(A043)
- AmpicillinSodium(A042)
- AmpicillinTrihydrate,USP(A009)
- AmpicillinTrihydrate,EP(A020)
ItisusedformicroBIOLOGicalinvitrosusceptibilitytests,andstudiesinpharmacokineticsandpharmacodynamics.
CASNumber
117060-71-6
MolecularFormula
Ampicillin:C16H19N3O4SSulbactam:C8H11NO5S
MolecularWeight
Mixture
MechanismofAction
Likeallβ-lactams,AmpicillininterfereswithPBP(penicillinbindingprotein)activityotherwiseinvolvedinthefinalphaseofpeptidoglycansynthesis.PBP’sareenzymeswhichcatalyzeapentaglycinecrosslinkbetweenalanineandlysineresidues.Withoutapentaglycinecrosslink,theintegrityofthecellwallisseverelycompromisedultimatelyleADIngtocelllysis.
TariffCode
2941.10.5000
Spectrum
AmpicillintargetsGram-negativenonESBL(ExtendedSpectrumβ-lactamase)bacteriaincludingStaphylococcusandStreptococcusandmedicallyimportantentericpathogenssuchasShigellaandSalmonella.Ampicillinhasbeenfoundtobeeffectiveagainstcertainβ-lactamsensitiveVREorvancomycinresistantEnterococcus;aglycopeptideantibioticresistant"superbug."
