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TOKU-E/Ticarcillin Disodium w/ Clavulanate Potassium (15:1) (Timentin)/10 g/T020-10 g
TicarcillinDisodiumw/ClavulanatePotassium(15:1)orTimentinisa15:1mixtureoftheantibioticticarcillindisodiumandthebeta-lactamaseinhibitor,clavulanatepotassium.
Ticarcillindisodium,isanextended-spectrum(4thgeneration)β-lactaminthecarboxypenicillinfamilythatactsasacellwallsynthesisinhibitor.Ticarcillinhasbactericidalactivityagainstmanygram-positiveandgram-negativebacteria,particularlyPseudomonasaeruginosa.Asabeta-lactamantibiotic,ticarcillinissusceptIBLetoß-lactamasedegradation.WhencombinedwithClavulanatePotassium(potassiumsaltofclavulanicacid),abeta-lactamaseinhibitor,ticarcillinsantibacterialactivityisgreatlyincreased.ClavulanicacidiseffectiveagainstorganismsexpressingclassAβ-lactamases(includingCTX-MandtheESBLderivativesofTEM-1,TEM-2,andSHV-1);andaregenerallylesseffectiveagainstclassB,C,andDβ-lactamases.
InplantBIOLOGy,timentinisusedmostcommonlyintheregenerationmediumforeliminationoftheAgrobacteriumpost-transformationofforeignDNAintoplantcells.
TOKU-Eofferstwoformsofticarcillindisodium:ticarcillindisodium(T027)andticarcillindisodiumw/clavulanatepotassium(15:1)(Timentin)(T020).Bothformsarefreelysolubleinaqueoussolution.
Thisproductisconsideredadangerousgood.Quantitiesabove1gmaybesubjecttoadditionalshippingfees.Pleasecontactusforspecificquestions.
CASNumber
116876-37-0
MolecularWeight
N/A
MechanismofAction
β-lactams,likeTicarcillinDisodium,USP,interferewithPBP(penicillinbindingprotein)activityinvolvedinthefinalphaseofpeptidoglycansynthesis.PBP’sareenzymeswhichcatalyzeapentaglycinecrosslinkbetweenalanineandlysineresiduesprovidingadditionalstrengthtothecellwall.Withoutapentaglycinecrosslink,theintegrityofthecellwallisseverelycompromisedandultimatelyleadstocelllysisanddeath.Resistancetoβ-lactamsiscommonlyduetocellscontainingplasmidencodedβ-lactamases. Clavulanicacidisa“suicide”or“mechanismbased”beta-lactamaseinhibitor.Clavulanicacidcontainsabeta-lactamringthatbindsstronglytobeta-lactamaseatornearitsactivationsite,therebypermanentlyinhibitingenzymaticactivity.Thisactionprotectsotherbeta-lactamantibiotics(penicillins,cephalosporins,etc.)frombeta-lactamasecatalysis,therebyenhancingtheirantibacterialactivity.
StorageConditions
2-8°C
TariffCode
2941.10.5000
Spectrum
Ticarcillindisodiumwithclavulanatepotassium(Timentin)hasabroadspectrumofactivity,includinggram-negativecocciotherthanenterococciandmethicillin-resistantstaphylococci;Enterobacteriaceae,includingdrug-resistantstrains;P.aeruginosa;andgram-positiveandgram-negativeanaerobes.
